Endocrine Abstracts

Rhesus macaques, like humans, express two molecular forms of gonadotropin-releasing hormone (GnRH-I and GnRH-II). Although the role of GnRH-I in the control of the reproductive axis is well-established, the physiological role of GnRH-II is less clear. Both forms of GnRH are highly expressed in the monkey hypothalamus and both forms are highly effective at stimulating LH and FSH release in vivo. However, estradiol appears to affect GnRH-I and GnRH-II gene expression diff...